Vanillyl Butyl Ether CAS 82654-98-6

Vanillyl Butyl Ether (VBE) is a highly efficient, oil-soluble warming active ingredient designed for cosmetic and personal care formulations requiring long-lasting thermal sensation and microcirculation stimulation.

Structurally derived from vanillyl moieties, VBE activates thermosensitive sensory neurons via interaction with the vanilloid receptor (TRPV1), triggering a sustained warming perception without significantly increasing actual skin temperature. This neuro-mediated thermal effect makes VBE particularly suitable for slimming, massage, winter care, and functional body care products.

Compared with traditional warming agents such as capsaicin or ginger extracts, VBE offers a milder irritation profile, longer-lasting heat sensation, and higher formulation stability, even at very low usage levels.

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Why Choose Vanillyl Butyl Ether?

Neuro-Activated Warming Mechanism

VBE binds to vanilloid receptors (TRPV1) on sensory neurons, opening calcium ion channels and inducing depolarization. This process stimulates the release of neurotransmitters (e.g. CGRP), leading to vasodilation and enhanced local blood circulation, perceived as a warm sensation.

Long-Lasting Heat with Low Irritation

Unlike aggressive thermal actives, VBE delivers a strong yet controllable warming effect that typically appears within 2 minutes and lasts up to 2 hours, with significantly reduced irritation risk.

Superior Performance at Low Dosage

Effective warming sensation can be achieved at concentrations as low as 0.1%, making it cost-efficient and formulation-friendly.

High Global Regulatory Acceptance

Approved for use in cosmetic and personal care products across China, Europe, the United States, and Japan.

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Key Benefits

• Provides rapid and long-lasting warming sensation

• Enhances microcirculation and skin vitality

• Supports subcutaneous fat metabolism in slimming formulations

• Low irritation compared with capsaicin-based actives

• Pleasant, mild vanilla-like odor

• Excellent stability across a broad pH range

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Typical Applications

• Body slimming & firming creams

• Thermal body lotions and massage oils

• SPA and circulation-boosting formulations

• Winter care products (hand creams, body creams)

• Lip plumpers (low-dose systems only)

• Heating masks and thermal patches

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Recommended Usage Level

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Technical Information

INCI Name: Vanillyl Butyl Ether
CAS No.: 82654-98-6
Molecular Formula: C₁₂H₁₈O₃
Molecular Weight: 210.27

Typical Specifications

Formulation Notes

• Oil-soluble; add during oil phase or post-emulsification

• Can be pre-solubilized with suitable solubilizers for aqueous systems

• Avoid prolonged high-temperature processing

• Recommended addition temperature: ≤ 45 °C

• Compatible with cooling agents to create hot-cold synergistic sensory effects

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Safety & Regulatory Status

• Patch test (0.4%): Negative

• Cytotoxicity (3T3 NRU phototoxicity test): Non-toxic

• Mutagenicity: Non-mutagenic

Regulatory Status:

• China: Approved for cosmetic use

• EU: Approved for cosmetic use

• USA: Approved for cosmetic use

• Japan: Approved for cosmetic use

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FAQ

Q: Does VBE increase actual skin temperature?
A: No. The warming sensation is neuro-mediated. Skin surface temperature shows minimal actual increase.

Q: Is VBE suitable for sensitive skin?
A: Yes, when used within recommended levels. Lower dosages are advised for lips and sensitive areas.

Q: Can VBE be combined with cooling agents?
A: Yes. VBE shows excellent synergy with cooling agents, enhancing cooling perception and duration.

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Supply & Documentation

The ingredient is supplied with complete technical and regulatory documentation, including:

• TDS

• SDS

• COA

• Safety & regulatory compliance support

• Formulation guidance upon request

Contact us to request samples, technical documents, or pricing information.

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