Decarboxy Carnosine HCl is a second-generation derivative of L-carnosine, developed to enhance anti-glycation efficacy and formulation compatibility in modern cosmetic systems. Unlike conventional antioxidants that primarily target oxidative stress, this ingredient specifically addresses non-enzymatic glycation, a key mechanism responsible for collagen stiffening, loss of elasticity, and premature skin aging.
Produced via a controlled condensation–deprotection synthesis route, Decarboxy Carnosine HCl offers high purity, excellent water solubility, and reliable stability. It is well suited for incorporation into advanced anti-aging, firming, and skin-protective formulations where long-term structural skin support is required.
Why Choose Decarboxy Carnosine HCl?
Targeted Anti-Glycation Mechanism
Acts as a competitive inhibitor of glycation reactions, reducing the formation of advanced glycation end-products (AGEs) that compromise collagen and elastin function.
Structural Skin Aging Protection
Addresses one of the root causes of skin stiffness and sagging rather than only surface-level aging symptoms.
High Formulation Compatibility
Water-soluble and easy to integrate into a wide range of emulsions, serums, and treatment products.
Suitable for Long-Term Use
Designed for daily leave-on skincare products with a favorable safety and stability profile.
Key Benefits
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Helps preserve collagen elasticity and skin firmness
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Delays glycation-induced aging and loss of skin resilience
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Improves overall skin texture and suppleness
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Supports long-term anti-aging and barrier protection strategies
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Suitable for premium and functional skincare product lines
Typical Applications
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Anti-aging serums and creams
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Firming and lifting treatments
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Protective day creams and barrier-repair products
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Intensive ampoules and concentrates
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Sheet masks and treatment essences
Recommended Usage Level
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Leave-on skincare products: 0.1 – 1.5%
The optimal dosage should be determined based on formulation type, target claims, and compatibility testing.
Technical Information
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INCI Name: Decarboxy Carnosine HCl
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CAS No.: 57022-38-5
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Molecular Formula: C₈H₁₄N₄O · 2HCl
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Molecular Weight: 255.14 g/mol
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Appearance: White to off-white powder
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Purity (HPLC): ≥ 98.5%
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Solubility: Freely soluble in water
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Odor: Odorless
Formulation Notes
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Add to the aqueous phase with proper dissolution
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Compatible with pH 5.0–8.0 cosmetic systems
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Avoid strong acids, strong alkalis, and strong oxidizing agents
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Recommended processing temperature: below 60°C
FAQ
Is Decarboxy Carnosine HCl different from regular L-carnosine?
Yes. It is a structurally modified derivative designed to enhance anti-glycation performance and formulation stability in cosmetic applications.
What skin concerns is it best suited for?
It is particularly effective for glycation-related aging concerns such as skin stiffness, loss of elasticity, and firmness reduction.
Is it suitable for daily skincare products?
Yes. It is designed for long-term use in leave-on cosmetic formulations when used within recommended levels.
Can it be combined with other anti-aging actives?
Yes. It works well alongside antioxidants, peptides, moisturizers, and barrier-repair ingredients.
Supply & Documentation
Available with complete technical support, including:
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Technical Data Sheet (TDS)
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Safety Data Sheet (SDS)
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Certificate of Analysis (COA)
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Regulatory compliance support
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Formulation guidance upon request
Contact us to request samples, specifications, or pricing information.
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