Ergothioneine (EGT) is a naturally occurring thiol-based amino acid derivative recognized for its exceptional antioxidant and cytoprotective properties. It is biosynthesized through controlled fermentation using engineered microorganisms, ensuring high purity, sustainability, and consistent quality for cosmetic applications.
Unlike conventional antioxidants, Ergothioneine features a unique biological transport mechanism via the OCTN1 transporter, enabling selective cellular uptake and long-term retention in skin tissues. This targeted delivery allows EGT to provide sustained protection against oxidative stress, environmental aggressors, and photoaging, making it a highly valued active ingredient in advanced skincare formulations.
Why Choose Ergothioneine?
Unique Cellular Transport & Retention
Ergothioneine is actively transported into skin cells via the OCTN1 transporter, allowing it to accumulate and remain effective over extended periods—an advantage not shared by most topical antioxidants.
Multi-Pathway Antioxidant Protection
EGT neutralizes reactive oxygen species (ROS), chelates transition metal ions, and protects mitochondrial function, addressing oxidative damage at multiple biological levels.
High Stability & Formulation Compatibility
Compared to many antioxidant actives, Ergothioneine exhibits excellent chemical stability across a broad pH range, making it suitable for diverse formulation systems.
Global Market Acceptance
Widely studied and accepted for cosmetic use, Ergothioneine aligns with international regulatory expectations and is suitable for export-oriented formulations.
Key Benefits
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Provides long-lasting antioxidant protection against UV and environmental stress
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Helps reduce inflammation and soothe sensitive or stressed skin
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Supports skin brightening and tone uniformity by modulating melanogenesis pathways
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Delays visible signs of photoaging, including fine lines and loss of elasticity
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Enhances skin barrier resilience and cellular longevity
Typical Applications
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Anti-aging serums and creams
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Brightening and tone-evening formulations
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Protective day creams and urban defense products
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Post-sun care and repair treatments
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Sensitive skin and soothing skincare products
Recommended Usage Level
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Leave-on products: 0.1% – 3.0%
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Rinse-off products: 0.01% – 0.1%
Optimal dosage should be determined based on formulation type, target efficacy, and regional regulatory requirements.
Technical Information
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INCI Name: Ergothioneine
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CAS No.: 497-30-3
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Appearance: White to off-white crystalline powder
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Solubility: Water soluble
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pH Stability Range: 3.0 – 9.0
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Thermal Stability: Recommended addition below 50°C
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Functionality: Antioxidant, skin protectant, anti-inflammatory agent
FAQ
Is Ergothioneine suitable for sensitive skin formulations?
Yes. Ergothioneine is well-tolerated and particularly suitable for sensitive, stressed, or post-procedure skincare products.
Can Ergothioneine replace traditional antioxidants like Vitamin C or E?
EGT is often used alongside other antioxidants. Its unique cellular retention complements fast-acting antioxidants, creating a more complete protection system.
Is Ergothioneine stable in long-term formulations?
Yes. It offers superior stability compared to many conventional antioxidants, supporting long shelf life and formulation integrity.
Is it suitable for global markets?
Ergothioneine is widely accepted in international cosmetic markets and commonly used in premium skincare products.
Supply & Documentation
Available with complete technical support documentation upon request, including:
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TDS
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SDS
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COA
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Regulatory compliance support
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Formulation guidance for industrial-scale production
Contact us to request samples, technical documents, or pricing information.
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