Hydroxypinacolone Retinoate (HPR) is a next-generation retinoid ester that binds directly to retinoic acid receptors (RARs) in the skin—no conversion required. It delivers comparable anti-aging efficacy to traditional retinol with significantly lower irritation and superior stability (approximately 10x more stable than retinol)
To learn more: See our Complete HPR Science Guide for mechanism and clinical data, or HPR vs Retinol Comparison for formulation decision-making.
Product Specifications
| Parameter | Specification |
|---|---|
| Appearance | Yellow to orange crystalline powder |
| Purity (HPLC) | ≥99.0% |
| Melting Point | 85.0 – 95.0°C |
| Water Content | ≤0.5% |
| Heavy Metals | Pb ≤10ppm, As ≤2ppm, Hg ≤1ppm, Cd ≤5ppm |
| Total Bacterial Count | ≤200 cfu/g |
| Molds & Yeast | ≤100 cfu/g |
| Pathogens | Negative for E. coli, S. aureus, P. aeruginosa |
| Solubility | Oil-soluble (esters, triglycerides, DMI) |
| Storage | 2-8°C, sealed, away from light |
| Shelf Life | 3 years |
Certificate of Analysis (COA) Data
Each batch is tested according to enterprise standards. Representative COA data:
| Test Item | Specification | Typical Result |
|---|---|---|
| Purity (HPLC) | ≥99.0% | 99.6% |
| Free Tretinoin | ≤0.1% | 0.0% |
| Water Content | ≤0.5% | 0.21% |
| Lead (Pb) | ≤10mg/kg | Complies |
| Arsenic (As) | ≤2mg/kg | Complies |
| Total Bacterial Count | ≤200cfu/g | <10 cfu/g |
Why Choose Us as Your HPR Supplier?
| Feature | What It Means for You |
|---|---|
| ≥99% verified purity | Consistent performance batch after batch |
| Free tretinoin ≤0.1% | Safety-critical parameter controlled |
| Complete documentation | COA, MSDS, TDS with every shipment |
| Technical support | Formulation troubleshooting from experienced team |
| Flexible supply | 1kg, 5kg, 10kg, 25kg options; global logistics |
| Sample support | R&D samples available for evaluation |
Packaging & Logistics
| Parameter | Detail |
|---|---|
| Packaging options | 1kg/bag (aluminum foil, PE inner liner), 5kg/10kg bottle |
| Storage (bulk) | 2-8°C refrigeration, sealed, away from light |
| Shipping | Temperature-controlled logistics available |
| Documentation | COA, MSDS, TDS, commercial invoice, packing list |
Frequently Asked Questions (FAQ)
Q1: What is the minimum order quantity (MOQ) for Hydroxypinacolone Retinoate (HPR) powder?
A: For HPR powder (≥99% purity), our standard MOQ is 100g. For the 10% solution in DMI, the MOQ is 1kg as well. R&D samples are also available upon request. [Contact us for sample pricing →]
Q2: Do you provide COA, MSDS, and TDS for each batch?
A: Yes. We provide complete documentation (COA, MSDS, TDS) with every shipment. Each batch is tested for purity (HPLC ≥99%), heavy metals, microbiological limits, and physical parameters. You can request batch-specific COA before or after purchase.
Q3: What is the lead time for bulk Hydroxypinacolone Retinoate (HPR) orders?
A: For bulk orders (10kg–25kg), our typical lead time is 3–10 business days after payment confirmation, depending on your location and shipping method. Expedited shipping options are available.
Q4: Can I use Hydroxypinacolone Retinoate (HPR) in the same formulation with Vitamin C or AHAs?
A: HPR is more stable than retinol and can be formulated with Vitamin E, niacinamide, peptides, and ceramides. For Vitamin C (L-ascorbic acid) or AHAs/BHAs, we recommend separate products or AM/PM application to maintain optimal pH and stability. See our HPR Formulation Guide for detailed compatibility information.
Q5: Is Hydroxypinacolone Retinoate (HPR) suitable for sensitive skin formulations?
A: Yes. Clinical studies show HPR generates less than 50% of the inflammatory cytokine response (IL-1α) compared to equimolar retinol doses. This makes HPR an excellent choice for sensitive skin, eye contour creams, and first-time retinoid users.
Q6: How should I store Hydroxypinacolone Retinoate (HPR) raw material?
A: HPR powder should be stored at 2–8°C (refrigerated), sealed, and protected from light. Under these conditions, shelf life is 3 years. For finished products, we recommend airless, opaque packaging to extend stability.
Q7: Do you ship Hydroxypinacolone Retinoate (HPR) internationally?
A: Yes. We ship to North America, Europe, Southeast Asia, the Middle East, and South America via air or sea freight. Temperature-controlled shipping is available for sensitive ingredients. Contact us for a shipping quote to your location.
Q8: What is the difference between Hydroxypinacolone Retinoate (HPR) and retinol?
A: Unlike retinol which requires two-step conversion in the skin (retinol → retinal → retinoic acid), HPR binds directly to retinoic acid receptors (RARs). This means HPR works at lower concentrations (0.1–0.2% vs. 0.5–1.0% for retinol), is ~10x more stable, and causes significantly less irritation. See our detailed HPR vs Retinol Comparison for formulation decision-making.
Q9: Can I get a sample before placing a bulk order?
A: Yes. We offer R&D samples for evaluation. Sample lead time is typically 0–5 business days. Request a sample via email or WhatsApp.
Q10: Do you offer formulation support?
A: Yes. Our team provides formulation technical support, including solubility guidance, compatibility testing, stability optimization, and troubleshooting. Whether you are developing a serum, cream, or eye treatment, we can help you incorporate HPR successfully.
Request Samples & Get Quote
Contact us today for:
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Product samples (powder / 10% solution in DMI)
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Bulk pricing and supply chain solutions
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Complete technical documentation
Email: sales@gzhuachem.com
WhatsApp/WeChat: +8615217471609/+8618565278805
Website: https://gzhuachem.com/
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