Water-Soluble Vitamin C Derivatives
🔶 What is VC-IP
INCI: Ascorbyl Tetraisopalmitate | CAS No.: 183476-82-6
Ascorbyl Tetraisopalmitate(VC-IP) is a next-generation, esterified Vitamin C derivative designed for superior skin penetration. This oil-soluble (lipophilic) form ensures high stability and excellent bioavailability, converting into pure Vitamin C inside the skin, providing the same effective anti-aging, antioxidant, and brightening benefits without the irritation or instability of traditional Vitamin C.
🔶 Why It Matters
| Industry Problem | Our Solution (VC-IP) |
|---|---|
| Poor Stability: Pure VC oxidizes quickly, turns brown, and loses efficacy. | Exceptional Stability: Remains stable under heat (40-60°C) and light; over 98% purity verified by HPLC. |
| Difficult Formulation: Water-soluble VC requires low pH (<3.5), causing stinging. | Oil-Soluble & Gentle: Dissolves easily in oils/esters. Stable at pH 6.0 or lower; suitable for sensitive skin formulas. |
| Low Bioavailability: Pure VC struggles to cross the skin’s lipid barrier. | High Penetration: Achieves 14x higher intracellular VC levels vs. pure Ascorbic Acid. |
🔶 Key Benefits
- Powerful Brightening: Inhibits tyrosinase activity, reducing melanin synthesis by up to 83% (from 72% to 12% in testing).
- UV Damage Protection: Suppresses UV-induced p53 expression (DNA damage marker) and 8-OHdG release.
- Boosts Collagen Synthesis: Increases fibroblast collagen production by 170-195% (vs. 112-127% for pure VC).
- Anti-Aging (MMP Inhibition): Inhibits MMP-2 (18-23%) and MMP-9 (10-17%) activity to prevent collagen breakdown.
- Repairs Skin Barrier: Clinical tests show reduced TEWL (transepidermal water loss) and improved skin hydration.
- Regulatory Ready: Listed as a quasi-drug active in Japan and a functional whitening ingredient in Korea.
🔶 Typical Applications
- Whitening Serums & Creams
- Anti-Aging Emulsions
- Sunscreens
- Lipsticks & Color Cosmetics (adds gloss + antioxidant)
- Anhydrous Oils (brightening oils)
- Sheet Masks
🔶 Recommended Usage
| Product Type | Recommended Dosage |
|---|---|
| Leave-on Creams / Lotions | 1% – 5% |
| Anhydrous / Oil Serums | 5% – 20% |
| Sunscreen Products | 1% – 3% |
| Eye & Lip Care | 0.5% – 2% |
🔶 Safety & Compliance
- Toxicology Summary: Non-toxic, non-sensitizing, non-phototoxic. Suitable for leave-on formulations.
- Regulatory Status: Listed in China IECIC, EU/US/Japan/Korea/Australia personal care directories.
- Approvals: Japan’s “Quasi-drug” active; Korea’s official whitening functional ingredient; Taiwan’s “medicated cosmetic” listing.
- Quality: No heavy metals (Pb≤10ppm, As≤2ppm) | Microbial compliant (<200 cfu/g).
🔶 Basic Technical Info
| Parameter | Specification |
|---|---|
| Appearance | Colorless to light yellow liquid |
| Purity (HPLC) | ≥ 98.0% |
| Density (20℃) | 0.930 – 0.943 |
| Refractive Index (25℃) | 1.459 – 1.465 |
| Solubility | Soluble in oils, esters, hydrocarbons, ethanol. Insoluble in water/glycols. |
| Shelf Life | 3 years (cool, dry, airtight, dark storage) |
🔶 Why Work With Us
✔ Strict Quality Control: We verify every batch with COA, HPLC, and stability data (including heavy metal and microbial testing).
✔ Full Transparency: We provide complete safety data, regulatory files (including China原料报送码), and formulation guides.
✔ Formulation Support: Access to multiple reference formulas (anti-wrinkle cream, revitalizing essence, whitening oil).
✔ Reliable Supply Chain: We source directly from GMP-compliant production (2200㎡ R&D center, 400-ton annual capacity).
✔ Global Compliance: All products meet international standards (EU/US/JP/KR).
🔶 FAQ
- Q: How is Ascorbyl Tetraisopalmitate(VC-IP) different from pure Vitamin C (Ascorbic Acid)?
A: Pure VC is water-soluble, unstable, and can sting. VC-IP is oil-soluble, highly stable, and converts to VC inside the skin, offering 14x better delivery with no irritation. - Q: Can I use VC-IP in a water-based serum?
A: Yes, but it must be solubilized properly using a suitable emulsifier or solubilizer, as VC-IP is oil-soluble. We recommend keeping the final formula pH below 6.0. - Q: What concentration should I use for visible results?
A: Clinical data shows significant skin brightening and barrier repair effects with 2% VC-IP in a cream base. You can range from 1-5% for standard formulas. - Q: Does VC-IP cause photosensitivity?
A: No. Unlike some retinoids or AHAs, VC-IP is not phototoxic. In fact, data shows it helps protect DNA from UV-A and UV-B damage. - Q: What documentation do you provide?
A: We supply COA, TDS, MSDS, the official Chinese原料安全信息 (Raw Material Safety Information), stability data, and a formulation guide.
Ready to upgrade your brightening and anti-aging portfolio?
Our VC-IP (Ascorbyl Tetraisopalmitate) is in stock, fully certified, and ready for bulk orders.
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Water-Soluble Vitamin C Derivatives
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