Hexamidine Diisethionate CAS 659-40-5

Hexamidine Diisethionate (CAS 659-40-5) is a high-performance, water-soluble cationic antimicrobial agent specifically designed for cosmetic and dermatological applications. It delivers potent, broad-spectrum efficacy against a wide range of bacteria, fungi, and yeasts, while being celebrated for its excellent skin compatibility and mildness profile. Consequently, it has become an indispensable ingredient for modern formulations that require reliable microbial control alongside superior skin tolerance, making it a gold-standard choice for sensitive skin care and targeted acne treatments.

---

Why Choose Hexamidine Diisethionate?

In the landscape of cosmetic preservation and active treatment, Hexamidine Diisethionate stands out as a superior, multi-functional solution. It effectively bridges the gap between high performance and skin safety.

• Targeted & Broad-Spectrum Efficacy: It shows exceptional potency against key cosmetic-relevant microbes, most notably against Cutibacterium acnes, making it highly effective for acne-prone skin formulations.

• Dual-Action Ingredient: It seamlessly functions as both a powerful active ingredient for specific skin concerns (e.g., acne, irritation) and as a highly effective preservative booster, enhancing the overall stability and shelf-life of your product.

• Excellent Safety & Mildness: With a well-documented history of low irritation, it is ideal for formulating products for sensitive skin, baby care, and post-procedure regimens, supporting cleaner and gentler brand narratives.

• Formulator-Friendly: Its water solubility, stability across a broad pH range, and compatibility with common cosmetic systems allow for easy integration into a wide array of product types, from clear serums to rich creams.

  ---

Key Benefits

• Powerful Antimicrobial Action: Provides reliable protection against a broad spectrum of Gram-positive and Gram-negative bacteria, molds, and yeasts.

• Specifically Effective Against Acne: Demonstrates a very low MIC (Minimum Inhibitory Concentration) against Cutibacterium acnes, directly addressing a primary cause of acne.

• Preservative System Enhancement: Boosts the efficacy of existing preservative systems, allowing for potential reduction of traditional preservatives and supporting mild preservation strategies.

• High Skin Compatibility: Exceptionally mild and non-irritating, suitable for even the most sensitive skin types and delicate areas.

• Water-Soluble & Stable: Easily incorporates into aqueous phases, remains stable under typical cosmetic formulation conditions, and does not discolor or degrade easily.

  ---

Typical Applications

Hexamidine Diisethionate is recommended for a diverse range of leave-on and rinse-off products where mild yet effective microbial control is paramount:

• Targeted Treatment Serums: For acne, sensitive, or irritated skin.

• Facial Toners & Essences

• Moisturizing Creams & Lotions (for face and body)

• Cleansing Lotions & Micellar Waters

• Sheet Masks & Treatment Patches

• Scalp Care & Anti-Dandruff Products

• Intimate Hygiene Formulations

  ---

Recommended Usage Level

• As a Preservative Booster / Antimicrobial: 0.01% – 0.1% in the final product.

• For Targeted Anti-Acne Efficacy: Up to 0.1%.

• Note: The optimal dosage should always be confirmed through challenge testing based on the final formula.

  ---

Technical Information

---

FAQ

Q1: Is Hexamidine Diisethionate a preservative?
A: It is primarily a powerful antimicrobial agent. While it can provide some preservative efficacy, it is most commonly and effectively used as a preservative booster to enhance and support a broader preservation system, often allowing for reductions in other preservative concentrations.

Q2: Is it suitable for “clean beauty” or “sensitive skin” formulations?
A: Yes, absolutely. Its excellent mildness profile and non-irritating nature make it a preferred choice for clean, sensitive skin, and baby care product lines. It helps brands achieve effective preservation with a gentler ingredient story.

Q3: How does it compare to traditional preservatives like parabens?
A: Hexamidine Diisethionate offers a modern alternative with a different mechanism of action and a favorable safety perception. It is often used to complement or partially replace traditional preservatives, creating systems that are both effective and market-aligned with current consumer preferences.

Q4: Can it be used in combination with other actives?
A: Yes. It is compatible with most common cosmetic ingredients, including other actives like niacinamide, vitamins, and peptides. Compatibility testing is always recommended for specific formulations.

---

Supply & Documentation

We are committed to providing consistent, high-quality ingredients backed by comprehensive technical support.

• Packaging:

  • 1 kg/bag: Aluminum foil bag with an inner PE ziplock for optimal moisture and light protection.

  • 25 kg/drum: Standard industry drum for bulk manufacturing.

• Full Documentation Support:

  Upon request, we provide all necessary documents for your regulatory compliance and quality assurance, including:

  • Certificate of Analysis (CoA)

  • Safety Data Sheet (SDS) / MSDS

  • Technical Data Sheet (TDS)

  • Microbiological Test Data

  • Formulation & Application Guidelines

---

Ready to enhance your formulations with reliable, skin-friendly protection? Contact our technical team today for samples, specifications, and collaborative support.