Azelamide MEA CAS 242132-61-2

Azelamide MEA is a scientifically engineered derivative of Azelaic Acid, designed to overcome the key formulation challenges of its parent compound while amplifying its biological activity. This water-soluble molecule serves as a pro-active ingredient, efficiently converting to Azelaic Acid on the skin to deliver targeted efficacy against hyperpigmentation, acne, and sebum overproduction. Its optimized structure provides superior solubility, stability, and skin tolerance, making it the formulator’s choice for next-generation clarifying and brightening skincare.

Why Choose Azelamide MEA?

For brands seeking the proven dermatological benefits of Azelaic Acid without its notorious solubility issues, grittiness, or formulation limitations, Azelamide MEA offers a superior, drop-in solution. It enables the creation of elegant, high-efficacy serums, gels, and emulsions at a fraction of the use concentration, streamlining R&D and expanding product design possibilities. By delivering enhanced bioavailability and reduced irritation potential, it allows you to market powerful, results-driven formulas suitable for even sensitive skin types.

Key Benefits

• Enhanced Brightening & Targeted Pigment Correction: Selectively inhibits tyrosinase in hyperactive melanocytes, effectively reducing melanin production to fade dark spots, post-inflammatory hyperpigmentation (PIH), and melasma without affecting normal pigmentation.

• Potent Anti-Acne & Sebum Regulation: Exhibits strong antibacterial activity against C. acnes and other acne-related bacteria. Competitively inhibits 5-alpha reductase, reducing hormone-driven sebum production for long-term oil control and clearer skin.

• Improved Keratinization & Pore Health: Helps normalize skin cell turnover and reduces the synthesis of filamentous keratin, preventing follicular plugging and the formation of comedones (blackheads and whiteheads).

• Excellent Solubility & Formulation Flexibility: Highly water-soluble, enabling effortless incorporation into aqueous phases and clear formulas. It eliminates the grittiness and stability challenges associated with pure Azelaic Acid powder.

• High Efficacy at Low Concentrations: Demonstrates significant effects at usage levels as low as 0.2%-2.35%, offering cost-in-use advantages and formulation elegance compared to high-percentage Azelaic Acid dispersions.

Typical Applications

Azelamide MEA is ideal for a wide range of targeted treatment and daily care cosmetics:

• Brightening Serums & Dark Spot Correctors

• Anti-Acne Gels, Creams, and Treatment Serums

• Oil-Control Toners, Moisturizers, and Primers

• Gentle Exfoliating & Pore-Refining Products

• Soothing Creams for Blemish-Prone, Sensitive Skin

Recommended Usage Level

• General Brightening & Sebum Control: 0.5% – 1.5%

• Targeted Anti-Acne & Spot Correction: 1.5% – 2.35%

• Note: Optimal concentration should be determined based on final formulation type and desired claim strength. It is heat-stable and can be added during the aqueous phase prior to emulsification.

Technical Information

• INCI Name: Azelamide MEA

• CAS Number: 242132-61-2

• Appearance: White to off-white crystalline powder

• Solubility: Highly soluble in water

• pH Stability: Stable across a broad cosmetic pH range

• Key Mechanism: Serves as a precursor, converting to active Azelaic Acid on the skin to exert its multi-target benefits.

• Storage: Store in a cool, dry place in a tightly sealed container, protected from light. Shelf life up to 3 years under proper conditions.

FAQ

1. How is Azelamide MEA different from Azelaic Acid?
Azelamide MEA is a derivative with a monoethanolamide group, granting it excellent water solubility and superior formulation compatibility. It acts as a pro-active, converting to Azelaic Acid on the skin. This allows for lower use concentrations (typically 0.2%-2.35%), smoother textures, and potentially enhanced skin delivery compared to Azelaic Acid powders or suspensions which require high concentrations (10-20%) and specialized dispersion techniques.

2. Is it suitable for sensitive or rosacea-prone skin?
Yes. Its mechanism is inherently selective, targeting abnormal cells. The derivative form and lower required concentrations often translate to a reduced irritation profile compared to high-percentage Azelaic Acid, making it a gentler option for formulations targeting sensitive or reactive skin types.

3. Can it be combined with other active ingredients like Niacinamide or Salicylic Acid?
Absolutely. It pairs synergistically with Niacinamide for comprehensive brightening and barrier support. With Salicylic Acid, it offers a multi-pronged approach to acne (antibacterial + keratolytic). It is also compatible with most common cosmetic actives. Stability and efficacy in the final formulation should be verified.

4. What are the primary claims supported by this ingredient?
Clinically-relevant claims include: “Visibly reduces dark spots and hyperpigmentation,” “Helps clear acne and prevent breakouts,” “Minimizes excess oil and shine,” “Refines pores and skin texture,” and “Promotes a more even-toned, radiant complexion.”

5. Are there any specific regulatory or safety considerations?
It is designed for cosmetic use and compliant with international regulations when used within recommended concentrations. As a derivative, it avoids the solubility and particle-related challenges of Azelaic Acid. A full safety dossier is available upon request.

Supply & Documentation

We guarantee a stable supply of high-purity Azelamide MEA to support your product development and manufacturing timelines.

Available Support & Documentation:

• Comprehensive Technical Data Sheet (TDS)

• Safety Data Sheet (SDS)

• Certificate of Analysis (COA) for each batch

• Stability and Compatibility Guidelines

• Formulation Application Notes

Value-Added Services:

• Bulk quantity options with competitive pricing

• Customized packaging solutions

• Regulatory compliance guidance for key markets

• Samples available for evaluation and testing

Contact us to request samples, technical documents, or pricing information.