Hydroxyphenyl Propamidobenzoic Acid CAS 697235-49-7

Dihydroavenanthramide (Hydroxyphenyl Propamidobenzoic Acid) is a clinically validated, multi-functional bioactive compound derived from Oats (Avena sativa). Moving beyond its traditional use as a soothing agent, modern science has isolated and standardized this powerful ingredient to target the root causes of skin sensitivity, inflammation, and pruritus (itch). It provides formulators with a gold-standard, nature-inspired solution for creating high-performance skincare that delivers immediate comfort and visible skin barrier improvement.

Why Choose Dihydroavenanthramide?

In a market saturated with soothing claims, Dihydroavenanthramide stands out due to its multi-target, evidence-based efficacy:

• Clinically Proven, Multi-Pathway Action: Unlike single-mechanism ingredients, it works synergistically to inhibit the release of pro-inflammatory cytokines (like TNF-α and IL-8), scavenge free radicals, and modulate neurosensory pathways responsible for itch signaling. This triple action ensures comprehensive relief from irritation.

• The Gold Standard for Sensitive Skin: Its exceptional biocompatibility and proven efficacy in conditions like eczema and contact dermatitis make it the ingredient of choice for formulations targeting reactive, sensitive, and compromised skin.

• Enhances Product Tolerance: Ideal for use alongside potent actives (like retinoids, AHAs) or in post-procedure skincare to mitigate potential side effects (redness, stinging), improving user adherence and comfort.

• Stable & Formulator-Friendly: This synthetic analog of natural oat avenanthramides offers superior stability and purity, ensuring consistent potency and performance in a wide range of formulations (pH 3.5-8.0), from serums to creams and cleansers.

 Key Benefits

• Rapid Anti-Itch & Anti-Irritant: Provides fast-acting relief from itching and stinging sensations, validated in clinical studies on dry, itchy skin.

• Potent Anti-Inflammatory: Significantly reduces redness (erythema) and calms skin by inhibiting key inflammatory mediators at the cellular level.

• Strengthens Skin Resilience: Helps fortify the skin’s natural barrier function, reducing reactivity to environmental stressors and allergens over time.

• Soothes & Comforts: Delivers an immediate soothing sensation, enhancing the subjective feel and perceived efficacy of the final product.

Typical Applications

Designed for efficacy-driven skincare, haircare, and topical wellness products:

• Facial Skincare: Calming serums, moisturizers for sensitive/reactive skin, post-retinol or post-acid treatment creams, redness-recorrectors, after-sun care.

• Dermatological & Body Care: Therapeutic creams for eczema, atopic dermatitis, psoriasis, contact dermatitis, and extremely dry skin (xerosis). Post-steroid therapy recovery formulations.

• Medicated Topicals: Adjuvant ingredient in antifungal creams, anti-dandruff shampoos, and products for conditions like ringworm or athlete’s foot.

• Personal & Hygiene Care: Gentle baby creams, diaper rash ointments, intimate wash lotions, soothing nasal sprays, and barrier repair emollients.

Recommended Usage Level

• Effective Range: 0.05% – 0.5%

• Standard Recommended Usage: 0.1% – 0.3%

• For targeted, intensive care applications (e.g., dermatological creams), levels up to 2.0% can be used effectively.

 Technical Information

• INCI Name: Hydroxyphenyl Propamidobenzoic Acid

• Source: Synthetic (Standardized for purity and potency)

• Appearance: Off-white  powder

• Solubility: Oil-Soluble

• Stability & Storage: Stable under standard formulation conditions. Store in a cool, dry place (<25°C/77°F) in a tightly sealed, light-protected container. Avoid exposure to moisture and excessive heat.

• Shelf Life: 36 months from the manufacturing date when stored under recommended conditions.

 FAQ

Q1: Is this ingredient natural or synthetic?
A: Dihydroavenanthramide is a bio-identical, synthetically produced molecule that replicates and standardizes the most active compound found in oats. This ensures batch-to-batch consistency, high purity (>99%), and reliable efficacy, overcoming the variability of natural oat extracts.

Q2: Can it be used in “clean” or “preservative-free” formulations?
A: Yes. It is a highly stable, single-molecule active suitable for minimalist and clean-beauty formulations. It does not act as a preservative, so an appropriate preservation system must be selected independently.

Q3: What is the difference between this and colloidal oatmeal?
A: Colloidal oatmeal is a fine powder containing a mixture of compounds. Our Dihydroavenanthramide is the isolated, concentrated bioactive molecule responsible for the core anti-itch and anti-inflammatory benefits. It offers higher potency per dose, exact dosing control, and clarity in clear formulations.

Q4: Is it safe for use on babies and sensitive populations?
A: Absolutely. Its mechanism is gentle and non-disruptive, making it highly suitable for baby care products, maternity skincare, and formulations for those with clinically diagnosed sensitive skin conditions.

Q5: Can it be combined with other active ingredients?
A: Yes, it is highly synergistic. It is commonly paired with:
* Barrier Repair Agents (Ceramides, Cholesterol, Niacinamide)
* Moisturizers (Hyaluronic Acid, Glycerin)
* Other Soothing Agents (Bisabolol, Allantoin)
* Potent Actives (Retinoids, Vitamin C) to improve tolerance.

 Supply & Documentation

We are committed to supporting your brand with premium-quality ingredients and comprehensive technical partnership.

• Available Packaging:

• 1 kg/bag: Aluminum foil bag with an inner PE ziplock for optimal moisture and light protection. Ideal for R&D, sampling, and small-batch production.

• 25 kg/drum: Secure, industry-standard drum for bulk manufacturing.

• Full Documentation Support:

We provide all necessary documentation to streamline your regulatory compliance and quality assurance processes, including:

• Certificate of Analysis (CoA)

• Safety Data Sheet (SDS)

• Technical Data Sheet (TDS)

• Stability & Compatibility Guidance

• Clinical Dossier & Efficacy Claims Support

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Let’s formulate the next generation of soothing, high-performance skincare. Contact our technical sales team today for samples, formulation support, and partnership inquiries.

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